The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose and crospovidone in a fluid bed granulator dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.
Authors:Robert A. Mattes is an instrumentation scientist and Denise E. Root is marketing and process instrument manager at FOSS NIRSystems, Inc. (Laurel, MD).
Andrew P. Birkmire is a process engineer at GEA Pharma Systems, Inc. (Columbia, MD).
Address correspondence to: rmattes@ foss-nirsystems.com.